Benzotriazole-Mediated Synthesis and Antibacterial Activity of Novel N-Acylcephalexins

Faculty Pharmacy Year: 2016
Type of Publication: ZU Hosted Pages:
Authors:
Wael Mohamed Ali Ali Abdelhakiem
Journal: Scientia Pharmaceutica mdpi Volume:
Keywords : Benzotriazole-Mediated Synthesis , Antibacterial Activity , Novel N-Acylcephalexins    
Abstract:
Cephalexin (1) was acylated using N-acylbenzotriazoles (3a–k′) derived from various carboxylic acids including aromatic, heterocyclic and N-Pg-α-amino acid to afford N-acylcephalexins in excellent yields (82%–96%). Antibacterial screening of the novel cephalosporins revealed that all targets (4a–j) retained the antibacterial activity of cephalexin against Staphylococcus aureus (ATCC 6538). N-Nicotinylcephalexin (4c) and N-(3,4,5-trimethoxybenzoyl)cephalexin (4g) exhibited a broader spectrum of antibacterial activity towards standard strains of Staphylococcus aureus (ATCC 6538), Paenibacillus polymyxa (ATCC 842), and Escherichia coli (ATCC 10536) as well as a resistant strain of Pseudomonas aeruginosa (ATCC 27853).
    
     
 
       

Author Related Publications

  • Wael Mohamed Ali Ali Abdelhakiem, "Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma", MDPI, 2021 More
  • Wael Mohamed Ali Ali Abdelhakiem, "Xylitol Inhibits Growth and Blocks Virulence in Serratia marcescens", MDPI, 2021 More
  • Wael Mohamed Ali Ali Abdelhakiem, "Tackling Virulence of Pseudomonas aeruginosa by the Natural Furanone Sotolon", MDPI, 2021 More
  • Wael Mohamed Ali Ali Abdelhakiem, "Alteration of Salmonella enterica Virulence and Host Pathogenesis through Targeting sdiA by Using the CRISPR-Cas9 System", MDPI, 2021 More
  • Wael Mohamed Ali Ali Abdelhakiem, "Studies on Pseudomonas Cepacia Isolated from Cystic Fibrosis Patients and Narural Sourses. ", لايوجد, 1900 More

Department Related Publications

  • Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900 More
  • Mona Abdelmoniem Elsayed Mahmmoud , "Chemoantibiotic _ resistance in enteropathogenic Escherichia Coli Locally ", لايوجد, 1900 More
  • Mona Abdelmoniem Elsayed Mahmmoud , "Identification of different Candidia species according to its fatty acids contents.", لايوجد, 1900 More
  • Mona Abdelmoniem Elsayed Mahmmoud , "The effects of various antimicrobial agents against Escherichia coli isolated from urine.", لايوجد, 1900 More
  • Mona Abdelmoniem Elsayed Mahmmoud , "Isolation and Characterization of cellulose from Streptomyces roseoflavus ", لايوجد, 1900 More
Tweet