Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis, Antiproliferative, and Anti-Tubulin Activity

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 393
Authors:
Zakareyah Kamel Abdelsamie
Journal: Pharmaceuticals mdpi Volume: Pharmaceuticals 2020, 13, 393
Keywords : Potent Quinoline-Containing Combretastatin A-4 Analogues: Design, Synthesis,    
Abstract:
A novel series of quinoline derivatives of combretastatin A-4 incorporating rigid hydrazone and a cyclic oxadiazole linkers were synthesized and have demonstrated potent tubulin polymerization inhibitory properties. Many of these novel deri
    
     
 
       

Author Related Publications

  • Zakareyah Kamel Abdelsamie, "Regioselective hydroxysulphenylation of derivatives of allylic alcohols and amines.", Tetrahedron Letters, 1986 More
  • Zakareyah Kamel Abdelsamie, "New routes to heterocycles via sulphenylation of unsaturated amides", Tetrahedron Letters, 1987 More
  • Zakareyah Kamel Abdelsamie, "Trifluoroacetoxysulphenylation of unsaturated nitriles as a route to lactones", Tetrahedron Letters, 1986 More
  • Zakareyah Kamel Abdelsamie, "Synthesis of certain s-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of pharmaceutical interest", Eygpt J. Pharm. Sci, 1987 More
  • Zakareyah Kamel Abdelsamie, "Synthesis and biological activity of some novel triazolothiadiazines", Eygpt J. Pharm. Sci, 1988 More

Department Related Publications

  • Etedaal Hassan Mohamed Abdulaal, "18. In situ annelation of enaminones by reaction with methyleneiminium intermediates", لايوجد, 1900 More
  • Hanan Abdelraziek Abdelfattah Ali Hamied, "synthesis of some new imidazolones of expected antimicrobial activity", لايوجد, 1900 More
  • Azza Mohamed Kadry , "35. Synthesis and potentiometric study of some dioxadiaza ionophores in ion selective electrodes", لايوجد, 1900 More
  • Azza Mohamed Kadry , "16. Chemistry of quinazolines: Reinvestigation of the action of hydrazine on thioxo derivatives", لايوجد, 1900 More
  • Azza Mohamed Kadry , "2. Reaction and rearrangement of 2,4-quinazolinediones", لايوجد, 1900 More
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