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Tramadol HCl encapsulated niosomes for extended analgesic effect following oral administration
Faculty
Pharmacy
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Mahmoud Mokhtar AhmedIbrahiem
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Drug Delivery Science and Technology 46 Elsvier
Volume:
Keywords :
Tramadol , encapsulated niosomes , extended analgesic effect
Abstract:
Currently, proniosomes are generating a lot of interest in the field of drug delivery. They are characterized by high stability, extended drug release, ease of manufacturing, and rapid reconstitution and transformation into niosomes. The current study investigated Tramadol HCl (TH) encapsulation into niosomal vesicles using proniosome technology. Tween 80 (T80), Span 80 (S80), Tween 40 (T40), and Span 40 (S40) formed the backbones for niosome preparations. Encapsulation efficiencies (EE), vesicular sizes, in vitro release, and pharmacological activities of niosomal TH preparations were evaluated based on results from the hot plate test. Size distribution analysis showed homogenous vesicles with varied particle size that could be attributed to surfactant type and cholesterol (Chol) content. TH EE increased as a function of the increase in surfactant hydrophilic–lipophilic balance. TH release increased from all formulations as Chol% was increased from 0% to 50%. TH release from niosomal formulations with different surfactant types at 10% Chol increased in a specific order: S80 > S40 > T80 > T40. Following oral administration of TH niosomes to mice, the analgesic effects showed significantly extended effects compared to the TH solution. Oral administration of TH-encapsulated niosomes could be useful for extending the drug's analgesic effects.
Author Related Publications
Mahmoud Mokhtar AhmedIbrahiem, "Proniosomal oral tablets for controlled delivery and enhanced pharmacokinetic properties of Acemetacin", AAPS, 2014
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Mahmoud Mokhtar AhmedIbrahiem, "Taste masked orodispersible tablets of cyclosporine self-nanoemulsion lyophilized with dry silica", Pharmaceutical Development and Technology,, 2014
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Mahmoud Mokhtar AhmedIbrahiem, "Pharmaceutical Studies On Certian Multicomponents Colloid Drug Delivery Systems", لايوجد, 1900
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Mahmoud Mokhtar AhmedIbrahiem, "Pharmaceutical Studies On Certian Multicomponents Colloid Drug Delivery Systems", لايوجد, 1900
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Mahmoud Mokhtar AhmedIbrahiem, "Phase Study and Characterization of Certain Developed Multicomponent Colloidal Systems and their Potential Application As Carriers for An Antimicrobial Agent", لايوجد, 1900
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Department Related Publications
Ahmed Samer Zedan, "Controlled release of Diclofenac sodium from matrix tablet formulations.", لايوجد, 1900
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Ahmed Samer Zedan, "Process Analytical Technology: Nondestructive Evaluation of Cyclosporine A and Phospholipid Solid Dispersions by Near Infrared Spectroscopy and Chemical Imaging", لايوجد, 1900
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Azza Ali Hassan Solyman, "Design and in vitro characterization of small unilamellar niosomes as ophthalmic carrier of dorzolamide hydrochloride", Informa health, 2014
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Azza Ali Hassan Solyman, "Formulation and Evaluation of Timolol Maleate Loaded Niosomes as an Ocular Drug Delivery System", Bull.Fac.Pham.Cairo Univ., 2004
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Amr Selim Ahmed Ali Abu Lila, "Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs", Elsevier, 2014
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