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Solid Lipid Nanoparticles of Sulpiride: Improvement of Pharmacokinetic Properties
Faculty
Pharmacy
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Mahmoud Mokhtar AhmedIbrahiem
Staff Zu Site
Abstract In Staff Site
Journal:
International Journal of Pharmaceutical Investigation 9(3):122-127 International Journal of Pharmaceutical Investigation 9(3):122-127
Volume:
Keywords :
Solid Lipid Nanoparticles , Sulpiride: Improvement , Pharmacokinetic
Abstract:
Objectives: In this study, it is hypothesized that lipid carriers could enhance the pharmacokinetic behaviour of Sulpiride (Sul). Different Lipids such as Palmitic Acid (PA), Stearic Acid (SA) and triaplmitin (TA) were used to prepare Solid Lipid Nanoparticles (SLNs) which is then better characterized and tested for its in vivo bioavailability. Methods: SLNs were prepared using film homogenization technique. Different physicochemical parameters such as Homogenization Speed (HS), Homogenization Time (HT) and Sonication Time (ST) were evaluated. Surfactant type and concentration of surfactant, soy lecithin and lipid type were scrutinized. Finally, SLNs pharmacokinetic parameters were evaluated. Results: Sul Entrapment Efficiency (EE) and drug loading were highly associated with solubility in lipid and partition coefficients. The particle size was decreased with an increase in HT, HS and ST. According to lipid type, the EE was high using SA and low using TP. The EE was raised with an increment in the concentration of lipids and soy lecithin. Regarding the in vivo study, Sul SLNs showed 2.64 fold increase in relative bioavailability with higher Cmax (816.22 ng/ml) than the drug suspension
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Mahmoud Mokhtar AhmedIbrahiem, "Proniosomal oral tablets for controlled delivery and enhanced pharmacokinetic properties of Acemetacin", AAPS, 2014
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Mahmoud Mokhtar AhmedIbrahiem, "Pharmaceutical Studies On Certian Multicomponents Colloid Drug Delivery Systems", لايوجد, 1900
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Mahmoud Mokhtar AhmedIbrahiem, "Phase Study and Characterization of Certain Developed Multicomponent Colloidal Systems and their Potential Application As Carriers for An Antimicrobial Agent", لايوجد, 1900
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Ahmed Samer Zedan, "Physicochemical characterization and dissolution properties of rofecoxib complexes with cyclodextrins", لايوجد, 1900
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Ahmed Samer Zedan, "Preparation and characterization of rofecoxib solid dispersions with polyethylene glycols and urea", لايوجد, 1900
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Mahmoud Mokhtar AhmedIbrahiem, "Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes", لايوجد, 1900
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Amr Selim Ahmed Ali Abu Lila, "Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration", Elsevier, 2013
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