Conductometric determination of trospium chloride by silver nitrate and phosphomolybidic acid

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Manal Samer Abdelhamied Mahmoud Elmasry
Journal: ANNALES PHARMACEUTIQUES FRANCAISES Elsevier Volume:
Keywords : Conductometric determination , trospium chloride , silver nitrate    
Abstract:
wo simple, accurate, sensitive and precise conductometric methods were developed for determination of trospium chloride in pure form and in pharmaceutical formulations. It is based on using two precipitating reagents; Phosphomolybdic acid (PMA) and Silver nitrate (AgNO3). The mean recovery for Silver nitrate is in the range (98-100.95%) and for Phosphomolybdic acid in the range (98-101.69%). A molar ratio has been determined conductometrically for the two reagents, revealed (1/1) for (drug/reagent). The proposed methods were validated and successfully applied for the determination of the studied drug in pure form and in its pharmaceutical preparation. The results of the proposed methods were compared to the results of reported method with no significant difference between them. (C) 2020 Academie Nationale de Pharmacie. Published by Elsevier Masson SAS. All rights reserved.
    
     
 
       

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