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Simultaneous determination of Nebivolol hydrochloride and Valsartan in their binary mixture using different validated spectrophotometric methods
Faculty
Pharmacy
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Manal Samer Abdelhamied Mahmoud Elmasry
Staff Zu Site
Abstract In Staff Site
Journal:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy Elsevier
Volume:
Keywords :
Simultaneous determination , Nebivolol hydrochloride , Valsartan in their
Abstract:
Five simple, sensitive, accurate and precise spectrophotometric methods were developed for the simultaneous determination of Nebivolol hydrochloride (NEB) and Valsartan (VAL) in their binary mixtures and in pharmaceutical dosage form. The methods included Ratio Difference, First Derivative ratio, Mean Centering of ratio spectra, Bivariate and H-Point Standard additions method. The calibration curves were linear over the concentration range of 10–70 μg/ml and 20–60 μg/ml for NEB and VAL, respectively for Ratio Difference and First Derivative ratio method and over the concentration range of 10–70 μg/ml and 10–60 μg/ml for NEB and VAL, respectively for Mean Centering of ratio spectra, Bivariate and H-Point Standard additions method. These methods were examined by analyzing synthetic mixtures of the studied drugs and they were utilized to determine the studied drugs in their commercial pharmaceutical preparation. All methods were validated as per ICH guidelines and accuracy, robustness, repeatability and precision were found to be within the acceptable limits. The results of the proposed methods were compared to the results of reported methods with no significant difference between them.
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Manal Samer Abdelhamied Mahmoud Elmasry, "Instrumental Methods of Analysis for Certain Pharmaceutical Compounds", لايوجد, 1900
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Manal Samer Abdelhamied Mahmoud Elmasry, "The use of surface plasmon resonance band of green silver nanoparticles and conductometry for quantitative determination of minor concentrations of doxycycline hyclate and oxytetracycline HCl in pure and pharmaceutical dosage forms", Inderscience Publishers Ltd., 2020
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Manal Samer Abdelhamied Mahmoud Elmasry, "Novel in Situ Electrochemical Strategy for Gatifloxacin Microdetermination in Urine Using Solid Contact and Disposal Screen-Printed Electrodes: a Comparative Study", springer, 2021
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Manal Samer Abdelhamied Mahmoud Elmasry, "Earth-friendly-assessed chromatographic platforms for rapid analysis of sulfacetamide sodium and prednisolone acetate in presence of sulfanilamide impurity: Application on ophthalmic formulation and aqueous humor", elsevier, 2022
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Manal Samer Abdelhamied Mahmoud Elmasry, "Simple mathematical data processing method for the determination of sever overlapped spectra of linagliptin and empagliflozin in their pure forms and pharmaceutical formulation: Fourier self deconvulated method", Elsevier, 2021
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Department Related Publications
Hawaa Mohamed Khalil Salem Khalil, "Analytical Study of Protein of Milk & Milk Products ", لايوجد, 1900
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Magda Mohamed Elsayed Elhenawy, " New Methods for the Quantitative Determination of Certain Antihistaminic Drugs&Their Application in Pharmaceutical Preparations ", لايوجد, 1900
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Hisham Abdelaziz Mohamed Hashime, "The effect of the process variables on the HPLC separation of tricyclic neuroleptics on calixarene-bonded statinary phase", لايوجد, 1900
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Naglaa Abdelsatar Mohamed, "Utility of molybdophosphoric acid in qualitative and quantitative analysis of Sibutramine HCl, Sumatribtan succinate and Lomefloxacine HCl", international, 2012
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Magda Mohamed Ahmed Ayad , "Utility of molybdophosphoric acid in qualitative and quantitative analysis of Sibutramine HCl, Sumatribtan succinate and Lomefloxacine HCl", international, 2012
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