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Prostaglandin D2-ethanolamide induces skin cancer apoptosis by suppressing the activity of cellular antioxidants
Faculty
Pharmacy
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Eman Salah Abdelaziz Souliman
Staff Zu Site
Abstract In Staff Site
Journal:
Prostaglandins & Other Lipid Mediators Elsevier Inc.
Volume:
Keywords :
Prostaglandin D2-ethanolamide induces skin cancer apoptosis
Abstract:
The combined incidence of melanoma and non-melanoma skin cancer (NMSC) is greater than the incidence of all other malignancies in the US. Previously, we demonstrated that the endocannabinoid, arachidonoyl-ethanolamide (AEA), was a potent inducer of apoptosis in NMSC. The metabolism of AEA to the prostaglandin, PGD2-EA, was a prerequisite for AEA cytotoxicity. However, the mechanism of PGD2-EA cell death has not been clearly defined. In the present study, we report that PGD2-EA causes apoptosis in melanoma and NMSC cells. Mass spectrometry analysis revealed that PGD2-EA was dehydrated to three J-series prostaglandins; PGJ2-EA, Δ12PGJ2-EA, and 15deoxy,Δ12,14 PGJ2-EA. PGD2-EA inhibited the antioxidant activity of glutathione and thioredoxin which then caused oxidative stress. This increase in oxidative stress was accompanied by the activation of endoplasmic reticulum (ER) stress and apoptosis. The effect of PGD2-EA was independent of DP1, DP2, and PPARγ receptors suggesting that PGD2-EA cytotoxicity was mediated by its metabolic product, 15dPGJ2-EA.
Author Related Publications
Eman Salah Abdelaziz Souliman, "Synthesis and Evaluation of the Novel Prostamide, 15-Deoxy, Δ12,14-Prostamide J2, as a Selective Antitumor Therapeutic", American Associatiion of Cancer Research, 2017
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Eman Salah Abdelaziz Souliman, "Cannabinoids Modulate Neuronal Activity and Cancer by CB1 and CB2 Receptor-Independent Mechanisms", Experimental Pharmacology and drug discovery, 2017
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Eman Salah Abdelaziz Souliman, "Arachidonoyl-ethanolamide activates endoplasmic reticulum stress-apoptosis in tumorigenic keratinocytes: Role of cyclooxygenase-2 and novel J-series prostamides.", wiley online library, 2016
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Eman Salah Abdelaziz Souliman, "Receptor-dependent and receptor-independent endocannabinoid signaling: a therapeutic target for regulation of cancer growth.", Elsevier, 2013
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Eman Salah Abdelaziz Souliman, "Anandamide-induced endoplasmic reticulum stress and apoptosis are mediated by oxidative stress in non-melanoma skin cancer: Receptor-independent endocannabinoid signaling.", wiley online library, 2016
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Department Related Publications
Rasha Hassan Abdelghani Hassan , "Pharmacological Studies on the effects of Hstamine Centrally Admmistered in Rabbits .", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "The infleunce of chronic melatonin treatment on gonadotropins, sex", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "Hormonal changes induced by administration of tiaprofenic acid or naproxen", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "Effect of tiaprofenic acid or naproxen on the serum glucose level and liver", لايوجد, 1900
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Rasha Hassan Abdelghani Hassan , "A comparative study for the effect of glucose, fructose, sucrol and aspartame", لايوجد, 1900
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