Voltammetric Determination of Sulfaclozine Sodium at Sephadex-modified Carbon Paste Electrode

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Magda Mohamed Elsayed Elhenawy
Journal: ACTA CHIMICA SLOVENICA SLOVENSKO KEMIJSKO DRUSTVO, HAJDRIHOVA 19, LJUBLJANA 1000, SLOVENIA Volume:
Keywords : Voltammetric Determination , Sulfaclozine Sodium , Sephadex-modified Carbon    
Abstract:
The electrochemical behavior of Sulfaclozine Sodium (SLC) was studied at a bare and sephadex-modified carbon paste electrodes by cyclic voltammetry and square wave voltammetry. The cyclic voltammetry (CV) showed a well-defined irreversible oxidation peak at 0.94 V in Britton- Robinson buffer pH 7.0. The strong affinity of SLC to sephadex allowed accumulation of SLC at the surface of electrode and thus higher electrochemical sensitivity to SLC. The influence of sephadex loading, the pH of the solution and the scan rate on the peak current was studied. A linear calibration curve covering the concentration range from 0.005 to 1 mM was obtained using SWV. The method was successfully applied for the determination of SLC in the veterinary pharmaceutical formulations with satisfactory accuracy and precision.
    
     
 
       

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