Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors

Faculty	Pharmacy	Year:	2020
Type of Publication:	ZU Hosted	Pages:	9671-9683
Authors:	Staff Zu Site Abstract In Staff Site
Journal:	New Journal of Chemistry Royal society of chemistry	Volume:	23

Keywords :	Design, synthesis, , biological evaluation , novel nicotinamide
Abstract:	Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads

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