Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 9671-9683
Authors:
Journal: New Journal of Chemistry Royal society of chemistry Volume: 23
Keywords : Design, synthesis, , biological evaluation , novel nicotinamide    
Abstract:
Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads
    
     
 
       

Author Related Publications

    Department Related Publications

    • Abd El Shafey Ibrahim Ahmed Ibrahim, "Optimizing halogenation conditions of N-halamine polymers and investigating mode of bactericidal action", Copyright © 2009 Wiley Periodicals, Inc., 2009 More
    • Abd El Shafey Ibrahim Ahmed Ibrahim, "Metabolomic profiling can differentiate between bactericidal effects of free and polymer bound halogen", لايوجد, 2010 More
    • Abd El Shafey Ibrahim Ahmed Ibrahim, "Macroscopic N-halamine biocidal polymeric beads", لايوجد, 2010 More
    • Abd El Shafey Ibrahim Ahmed Ibrahim, "Halamine polymers: 1. Preparation and characterization of new pyrimidinone biocidal polymers based on poly-4-vinylacetophenone", emerald, 2004 More
    • Abd El Shafey Ibrahim Ahmed Ibrahim, "Halamine polymers: 2. Preparation of new triazine-diones biocidal polymers by grafting polymerization”. Pigment and Resin Technology", Emerald Group Publishing Limited, 2004 More
    Tweet