Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 9671-9683
Authors:
Amany Mohamed Hosny Ghanem Mettwalli
Journal: New Journal of Chemistry Royal society of chemistry Volume: 23
Keywords : Design, synthesis, , biological evaluation , novel nicotinamide    
Abstract:
Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads
    
     
 
       

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  • Amany Mohamed Hosny Ghanem Mettwalli, "Synthesis of new Pyrimidine Derivatives of Expected Pharmaceutical Interest", لايوجد, 1900 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "New methods for the selective alkylation of 3-thioxo-1,2,4-triazin-5-ones", Tetrahedron letters, 2016 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "A novel method for the synthesis of 1-aryltetrahydroisoquinolines", journal homepage, 2016 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "Synthesis of imidazolidine‐2,4‐dione and 2‐thioxoimidazolidin‐4‐one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa", WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY, 2020 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition", ُElsevier, 2021 More

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