Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 9671-9683
Authors:
Journal: New Journal of Chemistry Royal society of chemistry Volume: 23
Keywords : Design, synthesis, , biological evaluation , novel nicotinamide    
Abstract:
Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads
    
     
 
       

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