Design, synthesis, and biological evaluation of novel nicotinamide derivatives as potential histone deacetylase-3 inhibitors

Faculty Pharmacy Year: 2020
Type of Publication: ZU Hosted Pages: 9671-9683
Authors:
Amany Mohamed Hosny Ghanem Mettwalli
Journal: New Journal of Chemistry Royal society of chemistry Volume: 23
Keywords : Design, synthesis, , biological evaluation , novel nicotinamide    
Abstract:
Most of the FDA approved histone deacetylase inhibitors (HDACi) contain hydroxamate as the zinc binding group (ZBG). Hydroxamates form strong electrostatic metal chelation with divalent zinc present in HDAC. This strong zinc chelation leads
    
     
 
       

Author Related Publications

  • Amany Mohamed Hosny Ghanem Mettwalli, "Synthesis of new Pyrimidine Derivatives of Expected Pharmaceutical Interest", لايوجد, 1900 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "New methods for the selective alkylation of 3-thioxo-1,2,4-triazin-5-ones", Tetrahedron letters, 2016 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "A novel method for the synthesis of 1-aryltetrahydroisoquinolines", journal homepage, 2016 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "Synthesis of imidazolidine‐2,4‐dione and 2‐thioxoimidazolidin‐4‐one derivatives as inhibitors of virulence factors production in Pseudomonas aeruginosa", WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY, 2020 More
  • Amany Mohamed Hosny Ghanem Mettwalli, "Novel 1,2,4-triazine-quinoline hybrids: The privileged scaffolds as potent multi-target inhibitors of LPS-induced inflammatory response via dual COX-2 and 15-LOX inhibition", ُElsevier, 2021 More

Department Related Publications

  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors", mdpi, 2022 More
  • Tarek Mohamed Salah Rashad, "Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline–Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors", mdpi, 2022 More
  • Amany Mohamed Mohamed Elmahmoudy Sanger, "Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates", mdpi, 2022 More
  • Tarek Mohamed Salah Rashad, "New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors", mdpi, 2021 More
  • Tarek Mohamed Salah Rashad, "Novel chalcone/aryl carboximidamide hybrids as potent anti-inflammatory via inhibition of prostaglandin E2 and inducible NO synthase activities: design, synthesis, molecular docking studies and ADMET prediction", Taylor & Francis Group, 2021 More
Tweet