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Diclofenac mitigates virulence of multidrug-resistant Staphylococcus aureus
Faculty
Pharmacy
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Amira Mohamed Mohamed Ali Elganayny
Staff Zu Site
Abstract In Staff Site
Journal:
Archives of Microbiology Springer Berlin Heidelberg
Volume:
Keywords :
Diclofenac mitigates virulence , multidrug-resistant Staphylococcus aureus
Abstract:
Staphylococcus aureus is an opportunistic pathogen that has the ability to cause a wide range of diseases including superficial infection and severe invasive life threatening infections. The pathogenicity of S. aureus is mediated by a group of virulence factors that mediate the colonization and penetration. The antibiotic resistance of S. aureus has evolved due to the abuse of antibiotics rendering the cure of infection very difficult especially with the shortage in new antibiotic production. To combat this shortage, repurposing of FDA-approved drugs against the virulence factors is a new strategy. The analgesic drug Diclofenac was found to have anti-virulence activity against Pseudomonas aeruginosa and Proteus mirabilis. This study aimed to demonstrate the anti-virulence effect of diclofenac against clinical MRSA isolates phenotypically and genotypically using qRT-PCR.
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Amira Mohamed Mohamed Ali Elganayny, "Impeding efflux-mediated resistance in Staphylococcus aureus", A & V Publications, 2022
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Amira Mohamed Mohamed Ali Elganayny, "Integron occurrence is linked to reduced biocide susceptibility in multidrug resistant Pseudomonas aeruginosa", Taylor and Francis online, 2017
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Amira Mohamed Mohamed Ali Elganayny, "Studies on Virulence Factors of Candida Albicans", لايوجد, 1900
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Amira Mohamed Mohamed Ali Elganayny, "Phenotypic and Genotypic Detection of Beta-Lactams Resistance in Klebsiella pneumonia from Egyptian Hospitals Revealed Carbapenem Resistance by OXA and NDM Genes", Acedemic Journals, 2016
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Amira Mohamed Mohamed Ali Elganayny, "Aspergillus nidulans hypB encodes a Sec7-domain protein important for hyphal morphogenesis", Elsevier, 2008
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Department Related Publications
Eman Mahmoud Hassan Elmasry, "Studies on Chemoantibiotics Resistant patterns linked to Bacteriocin Production in Clinical Isolates of Gram -Negative Rods .", لايوجد, 1900
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Hassan Ahmed Abdelsalam Mohamed Badr, "Production of Aflatoxins by Immobilized Aspergillus flavus", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "The value of peritoneal lavage in peritonitis", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Effects of certain volatile oils on aflatoxins production by Aspergillus species locally isolated", لايوجد, 1900
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Mona Abdelmoniem Elsayed Mahmmoud , "Effects of some quinolones in adhesiom , haemagglutination , outer membrane proteins and plasmid prophile of uropathogenic Escherichia coli ", لايوجد, 1900
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