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Synchronous spectrofluorimetric determination of famotidine, fluconazole and ketoconazole in bulk powder and in pharmaceutical dosage forms
Faculty
Pharmacy
Year:
1997
Type of Publication:
Article
Pages:
25-46
Authors:
ElBayoumi, A, ElShanawany, AA, ElSadek, ME, AbdElSattar, A
DOI:
10.1080/00387019708002587
Journal:
SPECTROSCOPY LETTERS MARCEL DEKKER INC
Volume:
30
Research Area:
Spectroscopy
ISSN
ISI:A1997WG89300003
Keywords :
famotidine, fluconazole, ketoconazole, synchronous spectrofluorimetry, bulk powder, pharmaceutical dosage forms
Abstract:
The aim of this work was to investigate a simple and reliable method for the determination of trace amounts of famotidine, fluconazole and ketoconazole in bulk powder and in their pharmaceutical dosage forms. Also to study the different factors affecting the sensitivity of the synchronous technique in order to improve the measurement. The sample was prepared in methanol in case of famotidine and ketoconazole, and in water, after dissolution in methanol, in case of fluconazole. The fluorescence intensity was recorded at 384 (ex. at 284 nm), 285 (ex. at 255 nm) and 364 nm (ex. at 239 nm) for famotidine, fluconazole and ketoconazole respectively. The calibration curves were linear over the concentration ranges 15 - 50, 0.20 - 10 and 0.02 - 0.4 mu g/ml for famotidine, fluconazole and ketoconazole respectively.
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