The resurgence of bacteria that are resistant to most of all available antibiotics is a major challenge faced by scientists recently. Further research needs to be com- pelled to decipher other novel therapy to kill such multidrug-resistant bacteria. This nature of bacteriophage and the mechanisms of phage infection of bacteria are discussed herein. Also, we examined an existing body or research indicating the potential for a widespread application of phages as treatment therapy for many bacterial infections. Phages could be exploited as templates in efforts to fabricate nanomaterials for diverse application. Thus, mixed therapy of both phages and nanomaterials are in development and are used recently in vivo. Application of phage therapy-based nanoscience in breast cancer is discussed herein.