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Mevinolin production by some fungi
Faculty
Science
Year:
1997
Type of Publication:
Article
Pages:
477-480
Authors:
Shindia, AA
DOI:
10.1007/BF02826557
Journal:
FOLIA MICROBIOLOGICA FOLIA MICROBIOLOGICA
Volume:
42
Research Area:
Biotechnology \& Applied Microbiology; Microbiology
ISSN
ISI:A1997XV02200010
Keywords :
Mevinolin production , some fungi
Abstract:
The potentiality of twenty-five fungal species belonging to 14 genera isolated from Egyptian soils to produce mevinolin, a hypocholesterolemic agent, when grown on selected substrates was tested. For the first screening samples of culture filtrates were tested by TLC and the positive results were further estimated by HPLC analysis. It was found that nearly one-third of the tested fungi showed positive results as to production of mevinolin. Aspergillus terreus was distinguished by its capacity to produce mevinolin when cultivated on a selected medium. The maximum mevinolin yields were achieved after on 8-d incubation at 30 degrees C. An initial pH value of 5-6 was found to be the optimum for growth of A. terreus and mevinolin production.
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