Herein two experiments were conducted. The first experiment evaluated the antitumor activity of Arthrospira platensis (Spirulina platensis, SP) alone or in combination with cisplatin (CDDP) in Ehrlich ascites carcinoma (EAC) bearing mice. The second experiment assessed the outcomes of SP and/or CDDP administration on renal, hepatic, and bone marrow function in normal mice. The results showed that the EAC evoked a significant decrease in the mice survival rate, life span percentage, antioxidant defense system, and Caspase-3 immunoexpression but a significant increase in the viable cancer cells count, tumor and lipid peroxidation biomarkers concentrations, and Ki-67 immunoexpression. The EAC induced alterations improved to various degrees following SP and/or CDDP administration. SP minimized the oxidative hepatic and renal DNA-damaging and hematotoxic effect of CDDP. Overall, SP has a potent anticancer activity and could be used effectively as a hematinic and hepato-renal protective agent with anticancer drugs like CDDP.