Objective: This existing work was planned to appraise the interactive effect of both spirulina platensis and cinnamon in ameliorating the oxidative damage and the body weight increaseelicited by high- fat diet (HFD) ingestion in rats with investigating their hypolipidemic activity. Methods: we utilized in this study seventy five albino ratsof male sex with body weight ranging between 130-150 g. They were randomly grouped into 5 equal setswith 15 animals in every one. All groups were fed on HFD (20 % fat) for 4 weeksto cause obesity and hyperlipidemia except the 1st one was kept as normal control. Group 2 (positive control) was remained obese without any treatments, despite groups 3, 4 and 5 were orally given S. Platensis (500 mg /kg b.wt), cinnamon aqueous extracts (400 mg/kg b.wt) and a combined mixture of S. Platensis and cinnamon extracts at the previous doses respectively after inducing hyperlipidemia for another 4 weeks. With ending ofthis experiment, serum lipid profile, antioxidant and histopathological tests were performed with recording body weight gain. Results: Treating of obese rats with individual and combined doses of spirulina and cinnamon extracts showed a considerable decrease in the serumtriglyceride (TG), total cholesterol (TC), LDL, VLDL and tissue malondialdehyde (MDA) concentration with an elevation in the serum HDL level, tissue catalase (CAT) and superoxide dismutase (SOD) activities in comparison to obese group ( positive control), Also improved data was recorded in the body weight and histopathological picture. Furthermore, our results declared that the combined group of both plant and algae exhibited better effects comparing to the separated one. Conclusion: Co-administration of S. Platensis with cinnamon exerted more potent effects against hyperlipidemia and oxidative hazards in obese rats than each one separately, that may be a future aid tool for developing a novel challenge against obesity impacts.