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Role of mesenchymal stem cells and their culture medium in alleviating kidney injury in rats diabetic nephropathy
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Amal Al Shahat Ibrahim Al Shahat Al Naggar
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Medical Human Genetics Egyptian Journal of Medical Human Genetics
Volume:
Keywords :
Role , mesenchymal stem cells , their culture medium
Abstract:
Background: Diabetic nephropathy (DN) is considered as one of the most serious complications resulting from diabetes mellitus and end-stage of renal failure globally. Up to 40% of diabetic patients will develop DN. The involvement of mesenchymal stem cells (MSCs) in diabetic renal lesions management has been established in many animal models of DN. The aim is to evaluate the capability of MSCs and their culture medium (CM) to alleviate DN in streptozotocin (STZ)-induced diabetic rat model. Female albino rats were made diabetic and were further categorized into 4 subgroups of 15 each: DN group, DN group received fibroblasts, MSCs group received one dose of 1 × 106 cells of MSCs, and CM group received one dose of 500 μl of CM. In all groups, the treatment was delivered by intravenous injection (IV) into the tail vein. Results: MSCs insinuated themselves into the injured kidney as detected by CD44 expression. Biochemical and histological results showed that MSCs and/or CM effectively attenuated DN manifestations in rat model through their possible anti-inflammatory (tumor necrosis factor-α and transforming growth factor-β1 were decreased), antiapoptotic (Bcl2 was increased while Bax and caspases were decreased), and anti-oxidant role (malondialdehyde was decreased while glutathione and catalase were increased). Conclusion: These results provide a potential therapeutic tool for DN management through the administration of the CM from MSCs that ameliorates the effects of diabetes. It is also possible to treat DN using CM alone thus avoiding cell transplantation.
Author Related Publications
Amal Al Shahat Ibrahim Al Shahat Al Naggar, "POSTNATAL DEVELOPMENTAL CHANGES OF THE PROSTATIC GLAND IN ALBINO RAT", the journal of american science, 2013
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Amal Al Shahat Ibrahim Al Shahat Al Naggar, "HEPATO-PROTECTIVE EFFECT OF GREEN TEA EXTRACT ON CYCLOSPORINE A TREATED RABBITS: HISTOLOGICAL AND ULTRASTRUCTURAL STUDY", life science, 2013
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Amal Al Shahat Ibrahim Al Shahat Al Naggar, "POSSIBLE PROTECTIVE ROLE OF CALCIUM AGAINST FLUORIDE INDUCED CARDIO TOXICITIES IN ADULT MALE ALBINO RATS", the journal of american science, 2013
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Amal Al Shahat Ibrahim Al Shahat Al Naggar, "Protective effect of curcumin against toxic effects of sodium fluoride on lungs of adult male albino rats", the british journal of science, 2013
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Amal Al Shahat Ibrahim Al Shahat Al Naggar, "Mesenchymal stem cells and differentiated insulin producing cells are new horizons for pancreatic regeneration in type I diabetes mellitus", International Journal of Biochemistry and Cell Biology, 2017
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