Abstract Background: Ovarian cancer is one of the ten most frequent malignant tumors in female population with a high rate of mortality. The aim of this study: was to investigate health related quality of life among ovarian cancer women receiving chemotherapy at zagazig university hospitals. Design: A descriptive study design. Settings: The present study was conducted in the gynecologic oncology outpatient's clinic at zagazig university hospitals. Sample: Consisted of 75 women diagnosed with ovarian cancer and receiving chemotherapy. Tools of data collections: Three tools were used: Tool (1): An interview schedule including 3 parts: First part: to collect the socio-demographic characteristics, the second part for a reproductive history and third part for: Treatment modality, protocol of chemotherapy and problem encountered after ovarian cancer treatment. Tool (II): Cancer Patient Quality of Life Scale (EORTC QLQ-C30). Tool (III): Ovarian Cancer Quality of Life Scale (EORTC QLQ-OV28). Results: The highest affected dimensions of health related quality of life (EORTC QLQ-C30) were for physical functioning scale following by the role functioning scale and emotional functioning scale. Meanwhile the higher symptom scores for QLQ-C30 were found for fatigue, nausea and vomiting. The highest mean scores of ovarian cancer module QLQ -OV28 were body image and attitude to disease/treatment following by sexuality. Additionally the higher mean score for the symptoms scales on the OV-28 instrument were peripheral neuropathy and chemotherapy side effects (85.92& 80.95 respectively). Conclusion: It can be concluded that women with ovarian cancer and receiving chemotherapy experience high prevalence of chemotherapy symptoms that adversely affected their quality of life. Recommendation: Further research should be carried out to identify the best strategies to further integrate results of quality of life assessments in ovarian cancer treatment protocols and to examine the long-term effects of cancer and its treatment on patients and their families. Key Words: Ovarian cancer, Chemotherapy, Quality of life