Effect of Nursing Intervention on Improving Intellectual Education Teachers' Performance toward Students with Epilepsy Introduction: Epilepsy is one of the most common secondary disabilities in students with mental retardation among intellectual schools; the prevalence is increasing with the severity of the intellectual disability. About 50% of those with profound learning disability and between 10 and 20% of those with mild disability have suffered from seizures at some time in life. In the same line, epilepsy is one of the most common neurological disorders with a worldwide prevalence between 5 and 10 per 1000. Additionally, in Egypt, the prevalence was 6.98/1000. In Egypt, seizures are the most common cause of visits to pediatric neurologists. Approximately 50% of cases of epilepsy begin in childhood or adolescence. The prevalence rate was 12.9 per 1000 children, and in adolescence from 4-6 per 1,000 children. In addition, the prevalence of epilepsy is 9.3 per 1000, while the incidence rate is 1.5/1000. Epilepsy is slightly higher in males than in females. Therefore, it is vital that intellectual education teachers' should be provided with first-aid about epilepsy knowledge and practical training, and teaching should be compulsory. Aim of the study: The aim of this study was to evaluate the effect of nursing intervention on improving intellectual education teachers' performance toward students with epilepsy at Sharkia Governorate. Hypotheses: 1. Teachers’ knowledge and practices score toward students with epilepsy will be improved after nursing intervention sessions. 2. Teachers’ attitudes score toward students with epilepsy will be positive after nursing intervention sessions Subjects and Methods: Research design: A quasi-experimental design was used. Setting: The study was conducted at 13 intellectual schools at Sharkia Governorate. Study subjects: A purposive sample composed of 163 teachers from 13 intellectual schools working at least two years and accepts to participate in the study. Tools of data collection: Three tools were used to collect the necessary data for achieving the study objectives, Tool (I): Teacher’s knowledge about epileptic student, self-administered questionnaire. Tool (II): Teacher’s practice observation checklist. Tool (III): Teacher’s attitudes toward students with epilepsy scale. Results: The mean age of the studied teachers was 44.30±7.6 years. In addition, 60.7% of studied sample reside urban areas, and 90.2% of them were married. Only 11.7% of the studied teachers had sufficient and saving income. Moreover, 46.6% of the study teachers reported previous experience in intellectual school more than twenty years. The sources of teachers’ information for their knowledge about epilepsy were for most of them had their information from internet (55.8%), followed by health care professionals (43.6%), then TV (42.9%), and friends (28.8%). Statistically significant improvements were detected in the teachers' knowledge, practices, and attitudes in all phases of intervention from pre-sessions to immediately after and 3 months of post sessions (P <0.001). The total mean score of their knowledge increased from 9.61±3.30 in pre-sessions; to 19.35±1.73 immediately post sessions and 18.67±2.61, at 3 months of post sessions. The total mean score of their practices increased from 3.31±5.081 pre-sessions to 26.72±5.46 immediately post sessions and 24.83±6.71, at 3 months of post sessions. The total mean score of their attitudes increased from 13.62±2.25 in pre-sessions, to 16.38±1.83 immediately post sessions. Conclusion and recommendations: The present study concluded that teachers' performance was greatly improved immediately after implementation of nursing intervention. Unfortunately, this improvement slightly declined in the next three months (follow up test) but was still good, Therefore, the researcher recommended that educational nursing intervention about epilepsy should be provided periodically and continually to all teachers to equip them with the necessary knowledge and practices for proper management of students with epilepsy in the school.