Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Protective Role of Epigallocatechin Gallate in a Rat Model of Cisplatin-Induced Cerebral Inflammation and Oxidative Damage: Impact of Modulating NF-κB and Nrf2
Faculty
Pharmacy
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Hebatallah Husseini Mohamed Atteia
Staff Zu Site
Abstract In Staff Site
Journal:
Neurotoxicity Research Springer
Volume:
Keywords :
Protective Role , Epigallocatechin Gallate , , Rat Model , Cisplatin-Induced
Abstract:
Cisplatin is a widely used chemotherapeutic agent in treating various types of cancers. However, it can induce neurotoxicity and nephrotoxicity, limiting its dose and clinical use. Although previous studies indicated the direct link between cisplatin-induced central neurotoxicity and oxidative stress, the exact mechanism is not completely understood. Therefore, herein we investigated the effects of prophylactic and concurrent treatment with (−)-epigallocatechin-3-gallate (EGCG), a natural polyphenolic neuroprotective antioxidant, on cisplatin-induced brain toxicity in rats to delineate its molecular mechanism of action. We found that cisplatin initiated a cascade of genetic, biological, and histopathological changes in the brain cortex, inducing inflammatory cytokines, appearance of scattered inflammatory cells, nitro-oxidative stress, and apoptotic proteins in the cerebral cortex. However, EGCG not only protected against cisplatin-induced inflammatory burden but also ameliorated the induction of nitro-oxidative stress and apoptotic proteins triggered by cisplatin in the cerebral cortex of pre- and co-treated rats with respect to their unprotected counterparts. EGCG anti-inflammatory effect here may be attributed to the downregulation of nuclear factor kappa B (NF-κB). Additionally, this natural polyphenol significantly ameliorated cisplatin-elicited reduction in cerebral cortex brain-derived neurotrophic factor and acetylcholine esterase. Upregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its downstream heme oxygenase-1 (HO-1) by EGCG prophylactic and concurrent administration here seems also to play a key role in the protective impact of EGCG against cisplatin toxicity through enhancing total antioxidant capacity. Thus, EGCG can be used as a promising prophylactic adjuvant for preventing the development of brain inflammation and oxidative damage associated with cisplatin chemotherapy. Keywords Acetylcholine esterase . Apoptosis . Brain-derived neurotrophic factor (BDNF) . Cisplatin . (−)-Epigallocatechin-3-gallate . Oxidative damage . Proinflammatory cytokines
Author Related Publications
Hebatallah Husseini Mohamed Atteia, "Thymoquinone upregulates miR‐125a‐5p, attenuates STAT3 activation, and potentiates doxorubicin antitumor activity in murine solid Ehrlich carcinoma", wiley, 2021
More
Hebatallah Husseini Mohamed Atteia, "Dietary iron overload effect As Manipulated by fatty acids intake and their influence on testicular function", لايوجد, 1900
More
Hebatallah Husseini Mohamed Atteia, "Effect of prolonged intake of iron enriched diet on testicular functions of experimental rats", لايوجد, 1900
More
Hebatallah Husseini Mohamed Atteia, "Protective effect of resveratrol against doxorubicin-induced cardiac toxicity and fibrosis in male experimental rats.", Springer Link, 2014
More
Hebatallah Husseini Mohamed Atteia, "Renoprotective effect of a combination of garlic and telmisartan against ischemia/reperfusion-induced kidney injury in obese rats.", Taylor & Francis, 2016
More
Department Related Publications
Ahmed Mohamed Ahmed Ommar, "بعض الآثار السمية للمانكوزيب في العمال المعرضين والجرذان البيضاء البالغة ", لايوجد, 1900
More
Ahmed Mohamed Ahmed Ommar, "أثر التعرض للرصاص و الزنك علي الخصي والمني لذكور الجرذان البيضاء البالغة", لايوجد, 1900
More
Sarah Alsayed Yousry Elrefaee, "دراسة اصابات الراس بمستشفى طنطا الجامعى", لايوجد, 1900
More
Fatima Yusuf Elsayed Farhat, "التغيرات الهستولوجية المحدثة باعطاء مادة الكادميوم فى القشرة الكلوية فى الفار الابيض", لايوجد, 1900
More
Madiha wAsif Mohammad Adly, "التأثير السمى للالومنيوم على الكلى ومستويات الحديد وتدالمنجنيز والالمونيوم فى مصل الفئران البيضاء الرضيعة", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف