Journal: |
J Heterocyclic Chem.
Wiley &Sun
|
Volume: |
|
Abstract: |
In our study, we aimed to synthesize novel, some biologically active compounds,
Azoles and Azines derivatives, that to be nitrogen-containing heterocycles,
and have their diverse therapeutic values. Thiosemicarbazide, 2, was
obtained from the attack of nitrogen of hydrazine to the carbon of heteroallene
function of compound 1. Triazolotriazole derivative, 4, was obtained from
the reaction of 2 with diethyl malonate. Cyclization of thiourea unit of compound
2 with heteroallene, 1, gave trazine, 6. Benzolyation of 2 using benzoyl chloride
formed triazole derivative, 8. Reaction of 2 and maleic anhydride gave
furothiadazine, 10. Cyclohexanopyrimidinthione, 12, was obtained from
cyclocondensation of cyclohexanone with 2. Triazole, 14, was obtained from2 and
ammonium isothiocynate under thermal condition. Reaction of 2 with ethyl
bromoacetate gave thiazole derivative, 16. [2+3] Cyclocondensation of acetyl acetone
with 2 provided pyrazole, 18. Triazolotriazole, 20, was obtained from formalin
and 2. Compound 2 suffers intramolecular base mediated cyclization affording
pyrazole, 21. Keeping 2 and propinaldehyde under reflux provided triazolotriazole,
24. Acylation of 2 by succinic acid formed pyridazine derivative, 27.
|
|
|