Abstract This study was conducted to assess the effect of some essential oil blend with black pepper oil or radish seed oil on performance, digestibility, serum biochemistry and phagocytosis of broiler chickens. A total of 300one-day old chicks Ross 308 were allocated into equal six groups; each containing five replicates (10 chicks / replicate). The dietary groups wereT1 (-ve control) fed on control diet, T 2 (+ve control) fed on basal diet with addition of essential oils mixture 1g / kg diet which consist of equal amount of parsley oil, carrot oil and mint oil, T3 fed on +ve control diet with addition of black pepper oil (0.25 g/kg diet), T4 fed on +ve control diet with addition of black pepper oil (0.5 g/kg diet) , T5 fed on +ve control diet with an addition of radish seed oil (0.25 g/kg diet)and T6 fed on +ve control diet with addition of radish seed oil (0.5 g/kg diet).The results related to growth performance showed that dietary supplementation of essentials oils to broiler chickens significantly increased the final body weight gain (FWG) when compared with-ve control group.In addition, T6 group had significant increased (P<0.05) FWG with significant decreased (P<0.05) feed intake than other groups. The best feed conversion ratio and protein utilization were in T4 &T6 when compared with other groups. Apparent digestibility of dry matter, crude protein and ether extract was improved by increasing the level of black pepper oil or radish seed oil. The group supplemented by radish seed oil (0.5 g/kg diet) exhibited significant increased (P<0.05) total protein, albumin and globulin values than other groups. Triacylglycerol, total cholesterol level, very low-density lipoproteins and lowdensity lipoproteins was significantly decreased (P<0.05) in T4 and T6 groups than other groups. Moreover, the highest level of high-density lipoproteins was detected in T6 group. The best phagocytic percent was detected in the group receiving black pepper oil (0.5 g/kg diet) than other groups. Dietary supplementation with radish seed oil at 0.5g/ kg had increased net profit and economic efficiency than other groups. Dietary supplementation with essential oil blend especiallywith0.5 g/kg diet from radish seed oil had improved growth performance and lipid profile; as well, black pepper oil supplementation enhanced the growth performance and phagocytosis in broiler chickens.