Aim: To test the influence of mancozeb (MCZ) on metabolic alterations in male albino rats. Methods: forty adult male rats weighing 120 ± 10 g were used, divided into four groups of ten animals for each and administered mancozeb (Anadol, 80 % WP) at doses (150, 300 and 600 mg / kg B. w / day) for 4 weeks. Hematological parameters and markers for liver, kidney and lipid profiles were determined. Results: Results showed mancozeb exposure induced abnormal and highly significant changes in hematological and biochemical activities during the exposure period. Also, the current investigation observed an obvious increase in the organs weight ratios of intoxicated rats. Conclusions: Mancozeb induced alterations in hematological indices may be a defensive mechanism against mancozeb toxicity through stimulation of leucopoiesis. In addition, hepatorenal toxicity and changes in lipid profile leading to physiological impairment.