The aim of this study is to evaluate the effects of mancozeb (MZ) - an organocarbamate fungicide - on some hematological parameters and biochemical indices related to kidney and liver functions, Mancozeb was administered orally by gavage at doses of 250 (MZ1) and 500 (MZ2) mg / kg body weight / day to male albino rats for 30 days. Treating male albino rats with mancozeb induced various hematological and clinical biochemistry changes. These changes include a significant decrease in total erythrocyte count (TEC), total leukocyte count (TLC), and significant elevation in mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH). Our findings showed that mancozeb had some effect on the clinical - biochemical parameters of male albino rat by elevation in plasma aspartate aminotransferase (AST), alkaline phosphatase (AKP) and acetylcholinesterase (AChE) activity, and albumin (Alb), total lipid (TL), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) content; while, blood urea nitrogen (BUN), creatinine and triglyceride (TG) concentrations were decreased. Also, the current investigation observed an obvious increase in the weight of liver, kidney, brain, and testes but, weight of and heart of intoxicated rats were decreased.