Synthesis of some new pyrimidines

Chlorolysis of pyrimidinethione 1 yielded chloropyrimidine 3, which reacted with arylamines to yield 4-arylaminopyrimidines 4a-c. Compounds 4a,b were condensed with benzaldehyde to afford pyridopyrimidines 6a,b, which underwent cyclization to pyirmidoquinazoline 7. Compound 3 reacted with ethyl glycinate to give pyrrolopyrimidine 9. Chloropyrimidine 3 reacted with acid hydrazide to afford hydrazides 10a,b that underwent intramolecular cyclodehydration to triazolopryimidine 11. Synthesis of furopyrimidine 13, thienopyrimidine 14 and 4-ethoxypyrimidine 15 was also described.