Synthesis, characterization of some pyrazine derivatives as anti-canceragents: In vitro and in Silico approaches

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Eman Elsayed Mohamed Hassan Tantawy
Journal: Journal of Molecular Structure Elsevier Volume:
Keywords : Synthesis, characterization , some pyrazine derivatives , anti-canceragents:    
Abstract:
we introduced the synthesis and characterizationof some novel pyrazine derivatives as chemotherapeutic anti-cancer agents. Some synthesized compounds showed potentcytotoxic activity against breast and lung cancer cell linesin vitro.Molecular docking showed that the synthesized derivatives are useful inhibitors for EGFR. We were finally able to identify Compounds 6, 8a ,9, 10, and especially 11 as new pyrazine lead compounds for EGFR inhibition. These compounds will be further against two cancer cell lines with introduction of the mode of action to get an overview of their biological action.
    
     
 
       

Author Related Publications

  • Eman Elsayed Mohamed Hassan Tantawy, "A Novel Synthesis of Spiro[1,2-b]quinoxaline and Spiroindeno[1,2-b]pyrazine Derivatives Via one-pot three component Reactions", كليه العلوم- جامعه الزقازيق, 2020 More
  • Eman Elsayed Mohamed Hassan Tantawy, "Eco-Friendly Synthesis of 1H-benzo[d]imidazole Derivatives by ZnO NPs Characterization, DFT Studies, Antioxidant and Insilico Studies", MDPI, 2023 More
  • Eman Elsayed Mohamed Hassan Tantawy, "Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells", Elsevier, 2020 More
  • Eman Elsayed Mohamed Hassan Tantawy, "Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches", Elsevier, 2020 More
  • Eman Elsayed Mohamed Hassan Tantawy, "Synthesis of novel bioactive pyrido[2,3-d] pyrimidine derivatives with potent cytotoxicity through apoptosis as PIM-1 kinase inhibitors", the Royal Society of Chemistry, 2023 More

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