Schizophrenia is one of the most serious psychiatric disorders. It has a significant individual, social, and economic pressure on both patients and their families. Each disease, especially chronic diseases, has been associated with different family burden like economic and care burden. Chronic psychiatric disorders such as schizophrenia have been associated with more family burden. Attitudes are defined as ‘predispositions to associate certain kinds of stimuli with certain kinds of responses’. Such responses are classified as affective, cognitive, and behavioral. Attitude towards mental illness shapes the way people with mental illness are treated in a society. Negative attitude obstructs social incorporation of these people, whereas positive attitude, believed by caregivers, offers support to the patient in prevention, early treatment, and rehabilitation. Psycho-educational family programs improve attitudes toward mental illness have been effective. Specifically, its effectiveness has been obvious on medication compliance, positive coping with stressors, and reducing the risk of relapse in the first year following hospital discharge. Several other studies have also showed the efficacy of family psycho-educational interventions in reducing family burden of patients with schizophrenia.