The aim of the present research is to identify the relationship between cultural intelligence and general Adjustment between different samples from Egypt and Malaysia. the sample Composed of (99) students with average age (21.2) years and standard deviation (1.2), and (51) newly graduated Egyptian expatriates in Saudi Arabia and working in some universities with an average age (33.6) years, the average age of the sample as a whole (26) years and seven months, with standard deviation (10.1), (64 males and 86 females). They applied the scale of cultural intelligence and the measure of general Adjustment. Using the T test, correlation coefficient, and regression analysis, the results showed that there is a statistically significant positive correlation at (0.01) between the dimensions of cultural intelligence and the general Adjustment in the present research sample. There is no statistically significant difference between the mean scores of males and females in the dimensions of the Cultural Intelligence Scale and the general Adjustment in the present research sample. There is a statistically significant difference between the mean scores of Malaysians and Egyptians in the total score of the Cultural Intelligence Scale as well as in three dimensions of the Cultural Intelligence in favor of Egyptians expatriate. There is a statistically significant difference between the mean scores of males and females in the general Adjustment in the current research sample in favor of males. There is a statistically significant difference between the mean scores of Egyptians and Malaysians in the general Adjustment in the current research sample in favor of the Egyptian expatriates. Cultural intelligence contributes to predicting the general Adjustment of the current research sample.