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Topical hydroquinone in the treatment of some hyperpigmentary disorders
Faculty
Medicine
Year:
1998
Type of Publication:
Article
Pages:
449-450
Authors:
AMER, M, Metwalli, M
DOI:
10.1046/j.1365-4362.1998.00499.x
Journal:
INTERNATIONAL JOURNAL OF DERMATOLOGY BLACKWELL SCIENCE LTD
Volume:
37
Research Area:
Dermatology
ISSN
ISI:000074704900015
Keywords :
Topical hydroquinone , , treatment , some hyperpigmentary disorders
Abstract:
Seventy patients (50 with melasma, 10 with freckles, and 10 with post-inflammatory hyperpigmentation) were admitted to this trial. Treatment in the form of 4\% hydroquinone (HQ) was applied topically twice daily for a maximum of 12 weeks. Patients were advised to avoid sun exposure and/or to use topical sunscreen during the entire period of treatment. All patients were examined at week 0 and at weeks 4, 8, and 12 of therapy. At each visit, the lesion size was determined and the pigmentary intensity of melasma, freckles, and the area of post-inflammatory hyperpigmentation (PIH) relative to a non-affected area of skin was rated on a four-point scale: 1, no difference; 2, mild pigmentation; 3, moderate pigmentation; 4, severe pigmentation. At the last visit, the overall response was rated as excellent, good, fair, or poor.
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