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clincopathologicall and prognostic value of immunohistochemical expression of cd44 (stem cell marker) and ki67 in serous ovarian cancer
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Mohamed Abdel Gawad Souleiman
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Pathology Journal of Clinical and Diagnostic Research
Volume:
Keywords :
clincopathologicall , prognostic value , immunohistochemical expression , cd44
Abstract:
Introduction: Failure of effective treatment of epithelial carcinoma of the ovary necessitates searching factors that lead to resistance to chemotherapy and recurrence. Cancer stem cell theory hypothesis provides an explanation of how small group of cells inside the tumour remain resistant to treatment. CD44 has been considered as cancer stem cell marker in multiple malignancies but its role in Ovarian Serous Carcinoma (OSC) is still controversial. Aim: To investigate the expression of stem cell marker CD44 and proliferative activity using Ki67 immunostaining in serous ovarian carcinoma and their relation to clinical and pathological variables and outcome of the patients. Materials and Methods: The present study was a prospective study done on 45 patients with serous ovarian tumours, the ovarian sections obtained from the patients were immunostained by CD44 and Ki67 immunohistochemical markers. The Overall Survival (OS), Disease Free Survival (DFS) and response to treatment were investigated and analysed. Results: Both CD44 and Ki67 were positive in patients with increased grade and advanced stage and the difference was highly statistically significant (p=0.001 and p<0.001, respectively). CD44 and Ki67 expression were higher in bilateral cancer with presence of lymph node and distant metastasis than in unilateral tumours without lymph node and distant metastasis. The present study found positive relation between CD44 and Ki67 expression (p=0.006). CD44 and Ki67 positive expression level in OSC had a significantly shorter 3-year DFS than the patient group with negative expression of CD44 and Ki67 (p=0.020 and p=0.002, respectively). Conclusion: This study demonstrated that CD44 and Ki67 expression were significantly associated with high grade and late stage serous ovarian carcinoma, and their high expression was associated with poor prognosis and resistance to chemotherapy, so proper quantification may play a vital promising function in choosing targeting therapy and predicting more better result outcome.
Author Related Publications
Mohamed Abdel Gawad Souleiman, "Prognostic Significance of Programmed Cell Death Ligand 1 (PD-L1), CD8+ Tumor-Infiltrating Lymphocytes and p53 in Non-Small Cell Lung Cancer:An Immunohistochemical Study", Turkish Journal of Pathology, 2017
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Mohamed Abdel Gawad Souleiman, "Prognostic impact of EGFR and cytokeratin 5/6 immunohistochemical expression in triple-negative breast cancer", Elsevier, 2017
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Mohamed Abdel Gawad Souleiman, "HYPOFRACTIONATED RADIOTHERAPY VERSUS CONVENTIONAL RADIOTHERAPY IN TREATMENT OF GLIOBLASTOMA MULTIFORME", PAN ARAB JOURNAL OF ONCOLOGY, 2011
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Mohamed Abdel Gawad Souleiman, "METRONOMIC CHEMOTHERAPY AS A PALLIATIVE TREATMENT IN POOR PERFORMANCE STATUS PATIENTS WITH ADVANCED EPITHELIAL OVARIAN CARCINOMA", springer, 2011
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Mohamed Abdel Gawad Souleiman, "Re-Irradiation in Recurrent High-Grade Glioma", The medical journal of cairo university, 2012
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Department Related Publications
Walid Elsayed Hamouda, "تقييم دور العلاج الكيماوي والاشعاعي قبل الجراحه في حالات السرطان المستقيم المستشري موضوعيا", لايوجد, 1900
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Walid Elsayed Hamouda, "مقارنةالعلاج الاشعاعى مع التمودال بالعلاج الاشعاعى المنفرد فى حالات اورام المخ من الدرجة الثالثة والرابعة", مجلة جامعة الزقازيق الطبية, 2006
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Walid Elsayed Hamouda, "مقارنةالعلاج الاشعاعى مع التمودال بالعلاج الاشعاعى المنفرد فى حالات اورام المخ من الدرجة الثالثة والرابعة", جامعه الزقازيق الطبيه, 2001
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Walid Elsayed Hamouda, "تقييم دور العلاج الكيماوى والاشعاعى قبل الجراحة فى حالات سرطان المستقيم المستشرى موضعيا", مجلة جامعة الزقازيق الطبية, 2006
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Reham Safwat Elsayed Fahmy, "دراسه مقارنه بين حقن عقار السيبسلاتين اسبوعيا ملازما للعلاج الاشعاعى فقط في حالات سرطان عنق الرحم المتقدم", مجله جامعه الزقازيق الطبيه, 2001
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