Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy
Faculty
Medicine
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Eman Hassan Abdelbary
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Pathology ScopeMed Publishing
Volume:
Keywords :
Predictive role , , , , YKL-40 , locally advanced rectal
Abstract:
Objective: Patients with locally advanced rectal cancer (LARC) need extensive surgical interference. Preoperative neoadjuvant chemoradiotherapy (CRT) shifts this extensive surgical procedure to another sphincter saving one as well as lowers patient’s morbid¬ity and mortality. Till now, there is no definite method to predict patients’ response to neoadjuvant CRT. Methods: REG IV and YKL-40 immunohistochemistry were evaluated in pre-treatment endoscopic biopsies from 42 LARC cases who received neoadjuvant CRT followed by sur¬gical interference. The findings were correlated with the clinico-pathological features, tumor response, and tumor regression grade of the post-operative specimens. Results: REG IV high expression was associated with advanced post-treatment patho-logical tumor status, post-treatment pathological nodal status and presence of lym¬pho-vascular invasion with statistical significance. Furthermore, it was correlated with a lower extent of tumor regression after neoadjuvant CRT. All patients with pathologi¬cal complete response exhibited negative/low REG IV expression and only 13.6% of the responders showed high REG IV expression with statistical significance. YKL-40 immuno¬histochemical expression was highly associated with the tumor regression rate where 85% of LARC patients with poor neoadjuvant CRT response highly expressed YKL-40 and 66.6% of patients with complete regression showed negative/low expression of YKL-40. Conclusion: Our findings implicate REG IV and YKL-40 as important predictors of neoad¬juvant CRT response in LARC.
Author Related Publications
Eman Hassan Abdelbary, "Baseline HDAC6 and TFF3 proteins overexpression as prognostic markers of lupus nephritis relapse", Society of diabetic nephropathy prevention, 2020
More
Eman Hassan Abdelbary, "Prognostic value of Nestin, TGFβ1 and epithelial-mesenchymal transition markers in non small cell lung cancer", Wolters Kluwer/ Lippincott, Williams & Wilkins, 2020
More
Eman Hassan Abdelbary, "IDH1 R132H protein expression and loss of Tbx2 and pSTAT3 proteins predict better outcome of patients with high-grade astrocytoma", Wolters Kluwer/ Lippincott, Williams & Wilkins, 2017
More
Eman Hassan Abdelbary, "Diagnostic utility of amylase α-1A, MOC 31 and CD 82 in renal oncocytoma versus chromophobe renal cell carcinoma", Medknow publications, 2020
More
Eman Hassan Abdelbary, "Evaluation of Fascin and MMP-9 expression as markers of invasion in urothelial carcinoma of the urinary bladder", IJAR, 2016
More
Department Related Publications
Amal Mohamed Mahmoud Mangoud, "The 2nd International Conference of Oncology Diagnostic Unit (the main theme: Hepatitis C Virus, the problem and Danger). 1 /5 /2004 المجلة المجلة", لايوجد, 1900
More
Amal Mohamed Mahmoud Mangoud, "General supervisor in the National Project of the Oncology Diagnostic Unit for reducing the Hepatitis C Virus infection and Liver tumors in Sharkiya Governorate. 1 /1 /2004 المجلة المجلة", لايوجد, 1900
More
Amal Mohamed Mahmoud Mangoud, "- Identification of Subpopulation of Lymphocytes in Bilharzial Carcinoma of Urinary Bladder Using immunoperoxidase Technique 1 /8 /1988 المجلة المجلة", لايوجد, 1900
More
Amal Mohamed Mahmoud Mangoud, "- Histopathological and Histochemical Study of Atrophic Stage in of Rhinoscleroma 1 /1 /1990 المجلة المجلة", لايوجد, 1900
More
Essameldeen Ismaiel Ahmed Sabaa, ". Evaluation of HER-2/neu protein expression in gastric carcinoma.", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف