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Utility of certain pi-acceptors for the spectrophotometric determination of perindopril
Faculty
Pharmacy
Year:
1998
Type of Publication:
Article
Pages:
1267-1271
Authors:
ABDELLATEF, HE
DOI:
10.1016/S0731-7085(97)00254-9
Journal:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS PERGAMON-ELSEVIER SCIENCE LTD
Volume:
17
Research Area:
Chemistry; Pharmacology \& Pharmacy
ISSN
ISI:000076285700006
Keywords :
pi-acceptors, spectrophotometric determination, perindopril
Abstract:
Simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of perindopril. The methods are based on the reaction of this drug as n-electron donor with 2,3-dichloro-5,6-dicyano-p-benzoquinone(DDQ)-7,7,8,8-tetracyanoquinodime thane (TCNQ), tetracyanoethylene (TCNE), chloranil (CL) and p-chloranilic acid (p-CA) as pi-acceptors to give highly coloured complex species. The coloured products are measured spectrophotometrically at 588, 843, 419, 550 and 520 nm for DDQ, TCNQ, TCNE, CL and p-CA, respectively optimization of different experimental conditions is described. Beer's law is obeyed in the range of 20-200 mu g ml(-1) and colours were produced in non-aqueous media and were stable for at least 1 h. Application of the suggested methods to perindopril tablets are presented. (C) 1998 Elsevier Science B.V. All rights reserved.
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