The researcher " Shireen Ahmed Taha Hassan " study aims to identify the (Effect of water exercise program on serotonin production rate, some indicators of fitness and quality of life parameters for women age "50-55"), The researcher used the experimental method of pre-after measurement for one experimental group. The sample included (18) femal of the femal members of the social club in Minya- Elkamh city, This program have continue for (10) weeks with three training modules (saturday, Monday, Wednesday), The results of this study showed that the training program designed by the researcher led to positive improvement in serotonin production rate, some indicators of fitness and quality of life parameters for women ,The researcher recommended the use of the proposed program for individuals whose conditions are similar to the research sample as a means of improving and raising the indicators of physical and physiological health.