Functionalization of 1,2,3-Triazole to Pyrimidine, Pyridine Pyrazole, and Isoxazole Fluorophores with Antimicrobial Activity

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Heussein Mostafa
Journal: European Journal of Anatomy spriger Volume:
Keywords : Functionalization , 1,2,3-Triazole , Pyrimidine, Pyridine Pyrazole, , Isoxazole Fluorophores    
Abstract:
The multi-component reaction of diacetyl triazole derivative with ethyl cyanoacetate and various aromatic aldehydes according to the conventional and solvent free methods leads to the corresponding 2-oxonicotinonitriles. A number of chalcones has been obtained via condensation of diacetyl triazole derivative with a variety of aromatic aldehydes. Heterocyclization of dichalcones with thiourea, hydroxyl amine, 3-aminocrotononitrile and hydrazine hydrate leads to a series of functionalized triazoles. Fluorescent properties of some products have been studied and characterized by λem.max 463–499 nm. A series of newly synthesized compounds demonstrate high antimicrobial activity against the tested microorganisms
    
     
 
       

Author Related Publications

  • Ahmed Heussein Mostafa, "Evaluation of the Curative and Protective Role of Fresh Chicory Juice in Treatment of Hepatic Fibrosis in Male Albino Rats", Scoups, 2021 More
  • Ahmed Heussein Mostafa, "Efficient biocontrol of Spodoptera littoralis by Aspergillus nidulans, an endophyte of Lantana camara", ٍSpringer, 2020 More
  • Ahmed Heussein Mostafa, "Synthesis and Biological Evaluation of Glycosides and AcyclicNucleosides Derived 2-Oxonicotinonitriles", Wiely, 2019 More
  • Ahmed Heussein Mostafa, "Novel Triazole-, Oxadiazole-, and Pyrazole-Nicotinonitrile Hybrids: Synthesis, DFT Study, Molecular Docking, and Antimicrobial Activity", ٍSpringer, 2022 More
  • Ahmed Heussein Mostafa, "Synthesis and biological evaluation of 2-Oxo/thioxoquinoxaline and 2-Oxo/thioxoquinoxaline-based nucleoside analogues", EBSCO, 2016 More

Department Related Publications

  • Maher Abdul Rahman Shams al-Din Safty, "Application of chemical reactions on thin-layer chromatography", لايوجد, 1900 More
  • weSam Saber Mohammed Shehab, "Synthesis,Characterization and Evaluation of the Anticancer and Antimicrobial Activities of Some Novel Benzazole and Benzazine Derivatives", Council for Innovative Research, 2013 More
  • Wael Salah AbdelHalim, "Spin quenching of transition metals deposited on MgO insulator and CdO semiconductor density functional calculations", Wiley, 2011 More
  • Wael Salah AbdelHalim, "CO adsorption on Ni, Pd, Cu and Ag deposited on MgO, CaO, SrO and BaO: Density functional calculations", elsevier, 2009 More
  • Walaa Helmy Fahmy Sheweny, "SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY OF NEW Y(ΙΙΙ) AND Zr(ΙV) CIPROFLOXACIN COMPLEXES", LATVIJAS ĶĪMIJAS ŽURNĀLS, 2010 More
Tweet