Functionalization of 1,2,3-Triazole to Pyrimidine, Pyridine Pyrazole, and Isoxazole Fluorophores with Antimicrobial Activity

Faculty Science Year: 2020
Type of Publication: ZU Hosted Pages:
Authors:
Ahmed Heussein Mostafa
Journal: European Journal of Anatomy spriger Volume:
Keywords : Functionalization , 1,2,3-Triazole , Pyrimidine, Pyridine Pyrazole, , Isoxazole Fluorophores    
Abstract:
The multi-component reaction of diacetyl triazole derivative with ethyl cyanoacetate and various aromatic aldehydes according to the conventional and solvent free methods leads to the corresponding 2-oxonicotinonitriles. A number of chalcones has been obtained via condensation of diacetyl triazole derivative with a variety of aromatic aldehydes. Heterocyclization of dichalcones with thiourea, hydroxyl amine, 3-aminocrotononitrile and hydrazine hydrate leads to a series of functionalized triazoles. Fluorescent properties of some products have been studied and characterized by λem.max 463–499 nm. A series of newly synthesized compounds demonstrate high antimicrobial activity against the tested microorganisms
    
     
 
       

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