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Assessment of calprotectin in ascitic fluid as a marker for spontaneous bacterial peritonitis diagnosis in cirrhotic patients
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Fayrouz Othman Salim Othman
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Internal Medicine Wolters Kluwer
Volume:
Keywords :
Assessment , calprotectin , ascitic fluid , , marker , spontaneous
Abstract:
Background Spontaneous bacterial peritonitis (SBP) is a serious infection of ascitic fluid in cirrhotic patients. High mortality associated with the delay in diagnosis and treatment. There is a need for an accurate and a rapid method for SBP diagnosis. Objectives We aimed to evaluate ascitic fluid calprotectin as a diagnostic marker for SBP. Patients and methods Forty four cirrhotic patients were divided into two groups, non-SBP group: 22 patients with cirrhotic ascites without evidence of SBP and SBP group: 22 patients with cirrhotic ascites and SBP diagnosed by positive ascitic fluid bacterial culture and an increase in polymorphonuclear leukocytes (PMNLs) count in ascites (≥250 cells/mm3). Ascitic fluid calprotectin levels were measured using enzyme-linked immunosorbent assay. Results There was a significant increase of ascitic fluid calprotectin, total leukocytic count, PMNLs, lactate dehydrogenase, and total protein in SBP group when compared to non-SBP group. There were significant positive correlations between white blood cell, ascitic fluid total leukocytic count, PMNLs, total protein, and model for endstage liver disease score values and ascitic fluid calprotectin among SBP group. Ascitic fluid calprotectin with cutoff value 620 ng/ml, showed a sensitivity of 90.91% and a specificity of 95.45%, in diagnosis of SBP with positive predictive value 95.2% and negative predictive value 91.3%. Conclusion Ascitic fluid calprotectin may be valuable in rapid diagnosis of SBP. Keywords: ascites, calprotectin, spontaneous bacterial peritonitis
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Department Related Publications
Ahmed Adel Hassan Muhamad, "دراسة سريرية مرضية لالتهاب الكبد الهلالى المتكاثر عند الاطفال", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "ثبات وظائف الكلى المزروعة فى المستقبلون للكلى ويعالجون بعقار السانداميسون متابعة طويلة المدى", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "دراسة الاجسام المضادة لمضادات الكارديولابيبين ومتلازمة الكارديولابيبين فى مرضى الروماتويد المفصلى", لايوجد, 1900
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Ahmed Adel Hassan Muhamad, "تأثير من انظمة التثبيط المناعى على انتاج مادة عوامل النمو المحولtof-B1 فى متلقى زرع الكلى", لايوجد, 1900
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