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Thrombophilia in hepatocellular carcinoma
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Fayrouz Othman Salim Othman
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Liver Journal springer
Volume:
Keywords :
Thrombophilia , hepatocellular carcinoma
Abstract:
Background: Chronic liver disease and hepatocellular carcinoma (HCC) can cause a disturbance in the coagulation system. In this study, we aimed to assess the risk factors for venous thromboembolism either acquired or hereditary in patients with HCC. Results: Serum levels of proteins C and S, AT activity, and lipoprotein (a) were significantly lower in both HCC and cirrhotic patients while homocysteine levels were significantly higher in HCC patients. The prevalence of activated protein C resistance (APCR) and factor V Leiden (FVL) mutation was higher in HCC patients but with no significant differences between the studied groups. With multivariate analysis, prothrombin time, Fbg, protein C and S deficiency, increased lipoprotein (a), hyperhomocysteinemia, APCR, and FVL mutation were independent risk factors for thromboembolic complications in HCC patients. Conclusions: Thrombophilic abnormalities are prevalent in HCC patients, and they have a substantial increased risk of venous thromboembolism. Keywords: Hepatocellular carcinoma, Liver cirrhosis, Venous thromboembolism, Thrombophilia
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