Association Between Genetic Polymorphisms of beta(2) Adrenergic Receptors and Nocturnal Asthma in Egyptian children

Background: Identification of the genetic basis of asthma may contribute to the discovery of effective asthma drugs. Objective: Our aim was to estimate the association between B-2 adrenergic receptor (ADRB2) polymorphisms and nocturnal asthma in Egyptian children. Methods: ADRB2 polymorphisms Gly16 and Glu27 were genotyped in 200 Egyptian children (90 with nocturnal asthma and 110 healthy controls) using allele-specific polymerase chain reaction. Results: The homozygous (Gly16) genotype significantly increased the risk of nocturnal asthma (odds ratio {[}On 3.2; 95\% CI, 1.3-7.7; P=.003), as did the Gly allele (OR, 1.8: 95\% CI, 1.2-2.8). Conclusions: Our study demonstrated that nocturnal asthma was associated with ADRB2 Arg/Gly polymorphisms but not with ADRB2 Gln/Glu polymorphisms.