Synthesis and Antibacterial Acivity of Some Novel Pyrimidine-Based Heterocycleseterocycles

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Atef Mohamed AbdelHamid Ali Hassn
Journal: russian journal of general chemistry Pleiades Publishing, Ltd Volume:
Keywords : Synthesis , Antibacterial Acivity of Some Novel Pyrimidine-Based    
Abstract:
Cyclization of 1,2-diamino-4(4-chlorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 2 with a variety of electrophilic reagents results in formation of a new series of pyrimidine heterocycles including pyrimidotriazepines, pyrimidotriazines and triazolopyrimidines. Some newly synthesized compounds are tested for their antibacterial activity against Gram-positive and Gram-negative bacteria.
    
     
 
       

Author Related Publications

  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Atef Mohamed AbdelHamid Ali Hassn, "synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines", elsevier, 2017 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives", Science Publishing Corporation, 2012 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Utility of 6-Aryl-5-Cyano-2-Thiouracil Derivative as a Precursor for the Synthesis of Some New Pyrimidines", scientific & academic publishing, 2013 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Intermolecular cyclization of cinnamoylisothiocyanate: A new synthetic entry for pyrimidine, triazine, and triazole candidates", Taylor & Francis, 2018 More

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