Addition–cyclization reactions of furan‑2‑carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Atef Mohamed AbdelHamid Ali Hassn
Journal: journal of the iranian chemical society springer Volume:
Keywords : Addition–cyclization reactions , furan‑2‑carbonyl isothiocyanate with nitrogen nucleophiles    
Abstract:
Heterocyclization of furan-2-carbonyl isothiocyanate 1 with a variety of aliphatic and aromatic nitrogen nucleophiles resulted in the formation of a new series of heterocycles including triazines, pyrimidines, oxadiazines, imidazolidines, thiadiazoles and their condensed candidates. The antibacterial screening for a group of the newly synthesized compounds showed that they possess moderate antibacterial activities against examples of Gram-positive and Gram-negative bacteria.
    
     
 
       

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  • Atef Mohamed AbdelHamid Ali Hassn, "synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines", elsevier, 2017 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives", Science Publishing Corporation, 2012 More
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