Addition–cyclization reactions of furan‑2‑carbonyl isothiocyanate with nitrogen nucleophiles as a synthetic route to novel azines and azoles of potential biological activity

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Atef Mohamed AbdelHamid Ali Hassn
Journal: journal of the iranian chemical society springer Volume:
Keywords : Addition–cyclization reactions , furan‑2‑carbonyl isothiocyanate with nitrogen nucleophiles    
Abstract:
Heterocyclization of furan-2-carbonyl isothiocyanate 1 with a variety of aliphatic and aromatic nitrogen nucleophiles resulted in the formation of a new series of heterocycles including triazines, pyrimidines, oxadiazines, imidazolidines, thiadiazoles and their condensed candidates. The antibacterial screening for a group of the newly synthesized compounds showed that they possess moderate antibacterial activities against examples of Gram-positive and Gram-negative bacteria.
    
     
 
       

Author Related Publications

  • Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015 More
  • Atef Mohamed AbdelHamid Ali Hassn, "synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines", elsevier, 2017 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives", Science Publishing Corporation, 2012 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Utility of 6-Aryl-5-Cyano-2-Thiouracil Derivative as a Precursor for the Synthesis of Some New Pyrimidines", scientific & academic publishing, 2013 More
  • Atef Mohamed AbdelHamid Ali Hassn, "Intermolecular cyclization of cinnamoylisothiocyanate: A new synthetic entry for pyrimidine, triazine, and triazole candidates", Taylor & Francis, 2018 More

Department Related Publications

  • Hamdy Aldedamony , "Studies on Portland Blast-Furnace Slag Cement with Limestone as a Retarder”", Indian J. Eng. & Sci, 1995 More
  • Hamdy Aldedamony , "” Influence oF Sulphate on the hardening of Calcium Silicate Products", iL-Cemento, 1993 More
  • Ayman AboulFotouh Gouda Sallem, "Spectrophotometric and spectrofluorometric methods for the determination of non-steroidal anti-inflammatory drugs: A review", Elsevier., 2013 More
  • Fathi Ahmed Abdul Latif Yassin, "Synthesis and Reactions of Oxadiazolo, Thiadiazolo and Triazolo Phthalazin-1(2H)-one Derivatives.", الهند, 2012 More
  • Ayman AboulFotouh Gouda Sallem, "Development and validation of a rapid stability indicating HPLC-method using monolithic stationary phase and two spectrophotometric methods for determination of antihistaminic acrivastine in capsules", e, 2014 More
Tweet