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Utility of 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrileas a precursor for the synthesis of some novel pyrimidines: antibacterial activity
Faculty
Science
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Atef Mohamed AbdelHamid Ali Hassn
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of the iranian chemical society springer
Volume:
Keywords :
Utility , 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrileas , precursor , , synthesis , some novel
Abstract:
The starting material 2-furan-2-yl-4-mercapto-6-methylpyrimidine-5-carbonitrile 3 was reacted with various reagents resulting in the formation of a group of new pyrimidines and condensed pyrimidines including quinazoline 6 tetrazolopyrimidine 12, pyrazolopyrimidines 14, 18, and 19, triazolopyrimidine 16, and pyrimidopyridazine 20. The antibacterial activity was evaluated for a group of the synthesized compounds against examples of Gram-positive and Gram-negative bacteria.
Author Related Publications
Atef Mohamed AbdelHamid Ali Hassn, "heterocyclization of thiouracil derivative: synthesis of thiazolopyrimidines, tetrazolopyrimidines and triazolopyrimidines of potential biological activity", elsevier, 2015
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Atef Mohamed AbdelHamid Ali Hassn, "synthesis and antimicrobial evaluation of some new pyrimidines and condensed pyrimidines", elsevier, 2017
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Atef Mohamed AbdelHamid Ali Hassn, "Synthesis and Electrochemical Behavior of Some New Pyridazine Derivatives", Science Publishing Corporation, 2012
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Atef Mohamed AbdelHamid Ali Hassn, "Utility of 6-Aryl-5-Cyano-2-Thiouracil Derivative as a Precursor for the Synthesis of Some New Pyrimidines", scientific & academic publishing, 2013
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Atef Mohamed AbdelHamid Ali Hassn, "Intermolecular cyclization of cinnamoylisothiocyanate: A new synthetic entry for pyrimidine, triazine, and triazole candidates", Taylor & Francis, 2018
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Department Related Publications
Maher Abdul Rahman Shams al-Din Safty, "Hydrogenation of wheat straw using molecular sieve catalyst", لايوجد, 1900
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Maher Abdul Rahman Shams al-Din Safty, "Conversion of wheat straw and sewage sludge into oil", لايوجد, 1900
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Maher Abdul Rahman Shams al-Din Safty, "circular dichorism and infrared study of 3-turn formation in repeat peptides of elastin", لايوجد, 1900
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Walaa Helmy Fahmy Sheweny, "Metal complexes of the fourth generation quinolone antimicrobial drug gatifloxacin: Synthesis, structure and biological evaluation", elseiver, 2010
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