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Synthesis, Characterization, and Cytotoxic Activity on MCF-7 Cell Line of Some Novel Metal Complexes With Substituted Benzimidazole Ligands
Faculty
Science
Year:
2013
Type of Publication:
Article
Pages:
46-56
Authors:
El-Seidy, Ahmed M. A, El-Zahany, Eman, Barakat, Atiat S, Youssef, Nabil S, Galal, Shadia A, Drweesh, Sayed A
DOI:
10.1080/15533174.2012.682691
Journal:
SYNTHESIS AND REACTIVITY IN INORGANIC METAL-ORGANIC AND NANO-METAL CHEMISTRY TAYLOR \& FRANCIS INC
Volume:
43
Research Area:
Chemistry; Science \& Technology - Other Topics
ISSN
ISI:000322305700009
Keywords :
benzimidazole complexes, cytotoxic activity, human breast cancer cell line (MCF-7), Schiff base metal complexes
Abstract:
A series of novel metal complexes with the Schiff base ligands 4-((((1H-benzo{[}d]imidazol-2-yl)methyl)imino)methyl) benzene-1,3-diol, H3L1, and (((1H-benzo{[}d]imidazol-2-yl)methyl) thio)propanenitrile, HL2, have been synthesized and identified by elemental and spectral (UV-vis, IR, 1H NMR, mass) analyses, molar conductivities, as well as magnetic moment measurements technique. The ligands behave either as neutral tridentate or bidentate ligand. The antitumor activity of the new compounds was tested against breast cancer cell line MCF-7. Ag and Cu complexes 2, 8 and 9 showed a remarkable smaller value of IC50 than that of the Tamoxifen, the standard. This would provide a new potential antitumor drug that deserves more attention.
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