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Pyrrolizidine alkaloids from Echium rauwolfii and Echium horridum (Boraginaceae)
Faculty
Pharmacy
Year:
1999
Type of Publication:
Article
Pages:
295-300
Authors:
Wink, M, El-Shazly, A, Abdel-All, M, Tei, A
Journal:
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES VERLAG Z NATURFORSCH
Volume:
54
Research Area:
Biochemistry \& Molecular Biology; Pharmacology \& Pharmacy
ISSN
ISI:000081323600001
Keywords :
Echium rauwolfii, Echium horridum, boraginaceae, pyrrolizidine alkaloids, capillary GLC
Abstract:
Echimidine was isolated from Echium rauwolfii and Echium horridum and identified by MS, H-1- and C-13 NMR as a major alkaloid. In addition, structures of 12 minor alkaloids were inferred from GLC and GLC-MS analyses: 7-angeloylretronecine, 7-tigloylretronecine, lycopsamine, 7-acetyllycopsamine, uplandicine, 7-angeloyllycopsamine, 7-tigloyllycopsamine, tigloyl isomer of echimidine, 7-angeloyl-9-(2-methylbutyryl)retronecine, 7-tigloyl-9-(2-methylbutyryl)retronecine, 7-angeloyl-9-(2,3-dihydroxybutyryl)retro and 7-tigloyl-9-(2,3-dihydroxybutyryl)retronecine. Both species had similar alkaloid profiles. Alkaloid extracts exhibited antibacterial effects with a MIC of 1.7 mg/ml in E. coli. Microscopic examination of E. coli treated with different subtoxic alkaloid concentrations (13-52 mu g/ml) revealed extensive filamentation.
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