Background : Salaries remains one of the most important factors that lead to strike, nursing personnel usually strike because they want higher wages and this demand increases because of the rise of the cost of living. So they have gone on strike to improve their economic and non-economic conditions. The present study aimed to assess role of the nurse managers during nursing personnel strikes at Mit-Ghamr hospitals. Setting: This study was conducted at Mit-Ghamr hospitals using descriptive design. Subjects and methods: A simple random sample of 249 of staff nurses and all nurse managers (48) were used. Data were collected using two tools; staff nurses' questionnaire and nurse managers' questionnaire. Study results illustrates that the first cause of nursing personnel strike was salaries followed by unsuitable working condition. As well, the first measure that was used by nurse managers to prevent strike was rapid intervention of management to know reasons of strike and try to solve. It can be concluded that staff nurses were the main category who participated in strike, and the main causes of strikes were salaries and unsuitable working condition. Consequently it is recommended that nurse managers should schedule periodical meetings with staff nurses to discuss their problems in the work place and try to solve them and staff nurses should attend training programs to increase their experience and responsibilities toward work.