I N continuation of our interest in synthesis of novel heterocycles with anticipated biological activity especially the antitumor activity.In this paper we have discussed synthesis and reaction of 1,3-diphenylpyrazol-4-carboxaldehyde 4 with acetophenone derivatives 1a–d, active methylene compounds, hydrazines and aniline derivatives to yield the expected derivatives 5a– d. Also, a series of penta-substituted pyridine derivatives 15a-e have been synthesized by onepot three component cyclocondensation reaction of 1,3-diphenylpyrazole-4-carboxaldehyde 1, malononitrile and thiol derivatives 13a–e in presence of triethylamine as a catalyst. Also, 2-(1,3-diphenyl-1H-pyrazol-4-yl)-3-(aryl)thiazolidine-4-one 20a-e has been synthesized from N-((1,3-diphenyl-1H-pyrazol-4-yl)methylene-aniline derivatives 11a-e and thioglycolic acid. Some of the synthesized derivatives were screened for their antitumor activity. All the newly synthesized compounds have been characterized by means of elemental analyses, IR, 1 HNMR, 13CNMR, MS and in some cases by comparison with the known properties of compound or by comparison with samples prepared by reported unambiguous routs.