Efficacy of Helicobacter pylori infection in hyperemesis gravidarum attracts a lot of attention and recently this microorganism has also been linked with hyperemesis gravidarum. The aim of this study was to investigate the efficacy of Helicobacter eradication on management of hyperemesis gravidarum. A total of 100 patients (group A) and 50 control subjects (group B) were enrolled in the study. All subjects were underwent for a complete clinical evaluation, abdominal ultrasound, Helicobacter pylori stool antigen test and rapid urease test. Patient with intractable vomiting were underwent for upper gastrointestinal endoscopy with histopathological examination. Non teratogenic regimen was taken for HP eradication in intractable cases for 14 days. There is statistical difference between two groups (p<0.05) as regarding prevalence of Helicobacter pylori where its prevalence among cases of hyperemesis gravidarum (69%) specially among intractable cases (80.9%) in comparison to control group (15%). The Helicobacter pylori eradication was 68.9% and has actual advantageous effect on treatment of hyperemesis gravidarum. There is powerful correlation between Helicobacter pylori and hyperemesis gravidarum. The eradication of Helicobacter pylori significantly has actual advantageous effect on treatment of hyperemesis gravidarum.