The evolving role of protein disulfide isomerase A3 in Egyptian bladder cancer patients

Faculty Veterinary Medicine Year: 2019
Type of Publication: ZU Hosted Pages:
Authors:
Mohammed Afifi Yousef Afifi
Journal: Gene .Elsevier B.V Volume: Volume 693
Keywords : , evolving role , protein disulfide isomerase , , Egyptian    
Abstract:
Background:ProteindisulfideisomeraseA3(PDIA3),anendoplasmicreticulumprotein,isexpressedinbladderofBCpatients.However,itsroleinBChasbeenelusivetillnow.Objectives:ThisstudywasconductedtoassesswhetherPDIA3geneexpressionwasassociatedwithincreasedoddsofBC,inparticularmuscle-invasiveBC(MIBC).Methods:Ninetythreepatientsunderwentcystoscopyandbladdertumorswerebiopsiedandhistologicallyas-sessed.Datacollectedincluding:patientdemographicsandclinicalcharacteristics.Biochemicalmarkers:hy-poxiainduciblefactor1-alpha(HIF-1α),interleukin6(IL-6),advancedoxidationproteinproducts(AOPP),Malondialdehyde(MDA),8-hydroxy2-deoxyguanosine(8-OHdG),andreducedglutathione(GSH)andmole-cularmarkerPDIA3geneexpressionweremeasured.Results:Accordingtothetumorgradeandstage,36patientswerefoundtohaveMIBC,27patientshavenonMIBC(NMIBC)and30patientshavenobladderlesions(controlgroup).PDIA3geneexpressionlevelhadthelargestcontributiontoamultivariablemodelforpredictingBC,whichachieved89.0%predictiveaccuracy.TheAUCfordiscriminatingMIBCsignificantlyincreasedfrom0.644to0.938whenbiochemicalmarkerswerere-placedbymolecularPDIA3markerinthefinalmodel.Conclusions:UsingPDIA3expressionalongwithpriorinformationofpatient'sage,bilharzialhistorywithgrosshematuria,canhelpclinicianspredictBC,discriminateMIBCanddecideconsequentlythemostpromisingtherapeuticmanagementinEgyptianpopulation.
    
     
 
       

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