Intracardiac thrombus is known as the common cause of cardiogenic cerebral ischemia and a useful clinical marker of thrombogenesis. This study aimed to predict the presence of intracardiac thrombosis by noninvasive method using NT‑pro‑brain natriuretic peptide (BNP) and D‑dimer evidenced by trans‑esophageal echocardiography (TEE). Methods: A total of 200 patients were included and referred to TEE for the detection of intracardiac thrombi. Measurement of NT‑Pro‑BNP and D‑dimer was done 2 h before the TEE examination. The patients were divided into two groups namely Group A with intracardiac thrombus and Group B without intracardiac thrombus. Results: There was an increased prevalence of intracardiac thrombus in diabetic hypertensive patients and transient ischemic attack patients. Intracardiac thrombus had significantly higher levels of Pro‑BNP and D‑dimer (P < 0.001). Using the receiver operating characteristic curve, the value of D‑Dimer level >788 ng/ml and NT‑Pro‑BNP >683 ng/ml predicted the presence of intracardiac thrombus. Conclusion: High value of NT‑Pro‑BNP and D‑dimer level can predict the presence of intracardiac thrombosis and its decreased value can predict the absence of thrombosis in patients with suspected intracardiac thrombi.