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Histopathological Changes Produced by Bispenol A in the Renal Cortex of Adult Male Albino Rats
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa MahmoudAhmed
Staff Zu Site
Abstract In Staff Site
Journal:
Gene Med. J. Cairo Univ.,
Volume:
Keywords :
Histopathological Changes Produced , Bispenol , , , Renal Cortex , Adult
Abstract:
Background: Bisphenol A (BPA) is an important endocrine disrupting chemical that is widely used in plastic containers and has tendency to accumulate in many organs and affect their functions. Aim: The aim was to clarify the effect of BPA on the histological structure of the renal cortex in adult male albino rat and to assess the efficacy of its withdrawal in amelioration of this effect. Materials and methods: This study was conducted on forty adult male albino rats which randomly divided into four groups (10 rats each). Group Ι served as negative control, Group ΙІ was vehicle group and received corn oil, Group ΙΙІ which received a daily oral dose of BPA 50 mg/kg body of weight for eight weeks and finally Group ΙV which received the same dose of BPA as group III then kept for another four weeks without treatment for spontaneous recovery (BPA recovery). Renal cortices were processed for light and electron microscope examinations. Blood samples were collected for biochemical parameters (urea and creatinine). The level of malondialdehyde (MDA) and catalase activity were estimated in the kidney tissue. In addition, the diameter of renal glomeruli and Bowman's space surface area were morphometically and statistically analyzed. Results: It was noticed that BPA led to degenerative changes in the renal cortex with partial improvement of such structural findings in the BPA recovery group. Compared with the control groups (negative control, corn oil), the BPA group showed no significant difference in body weights (P=.52) but there was a higher significant increase in kidney weights (P<.001). Comparing between the BPA-treated and BPA recovery groups, no statistically significant differences (P=.34) was reported. Tissue MDA, urea and creatinine levels showed significant increase (P<.001) while catalase activity was dramatically decreased (P<.001) in the in BPA-treated and BPA recovery groups with no statistically significant differences between BPA treated and BPA recovery groups. The glomerular histomorphometry showed a significant decrease in mean glomerular diameter but very statistically significantly higher mean Bowman's space surface area in the BPA-treated and BPA recovery groups than the control groups, with no significant difference between the BPA-treated and BPA recovery groups( P=.67, P=.61) respectively. Conclusion: The previous results supported that BPA had toxic effect on the renal cortex structure and the recovery from such effect might need more than four weeks
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Marwa MahmoudAhmed, "Effect of carbonated soft drinks consumption on the bone of Wistar albino rat: A histomorphometric study", Journal of American Science, 2016
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Marwa MahmoudAhmed, "Effect of Formaldehyde on Rat Testis Structure", Academia Anatomica International, 2017
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Marwa MahmoudAhmed, "Effect of Formaldehyde on Rat Testis Structure", Academia Anatomica International; volume 3 (2),, 2017
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Marwa MahmoudAhmed, "THE HAZARDS OF TRAMADOL ON THE LIVER STRUCTURE OF ADULT MALE ALBINO RATS AND THE POSSIBLE PROTECTIVE ROLE OF N-ACETYLCYSTEINE: HISTOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY", egyptian journal of anatomy, 2017
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Marwa MahmoudAhmed, "Changes in Rats’ Liver Structure Induced by Zinc Oxide Nanoparticles and the Possible Protective Role of Vitamin E", International Journal of Human Anatomy, Volume 1(3),, 2018
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