The negative effects of Coca Cola and Seven-Up on the bone were studied in adult Wistar albino rats n= (30). The animals were randomly divided according to the type of their drink into 3 equal groups n=(10); 5 males and 5 females; control group maintained on tap water, cola consumption group maintained on Coca Cola and non-cola consumption group maintained on Seven-Up. In cola consumption group both sexes showed a significantly higher thickness in cortical bone than those of control and non-cola consumption groups respectively. The thickness in females of cola consumption group was significantly higher than the males, whereas in non-cola consumption group the thickness was significantly higher in males. Cola and non-cola consumption groups showed a significantly lower trabecular bone percentages in both sexes than those of control group. The trabecular bone percentage in males of cola and non-cola consumption groups was significantly lower than in females. Therefore, CSDs adversely affected the cortical and trabecular bone, with more effect in males, particularly with Cola consumption. The consumption of these beverages would be a risk factor of osteoporosis and must be reduced as much as possible