ABSTRACT The peculiar features of the hepatosinusoidal blood flow decrease with age, shaped by pseudocapillarisation, represent a key factor in normal aging. The ability to dissect the certain pseudocapillarisation beneficial and detrimental function highlights a target for anti-aging. We performed anatomical and histological examinations of the young and old liver goats and identified ultrastructural changes associated with advanced age in the defenestration and capillarisation of the hepatic sinusoids. Furthermore, the accompanied secretory vascular endothelial growth factor (VEGF) crucial for liver sinusoids was measured at protein expression level. The old liver goats were exhibited constant age changes resulted in age-impaired defenestration with reduced porosity of the hepatic sinusoids, thickness of the endothelium lining, infrequent developmental basement membrane formation, and collagen deposition achieved in the space of Disse. In turn, the release of secretory VEGF was significantly lowered in old goat livers. Overall, these findings suggest that the aging goat livers are impaired because of decline in the fenestration of hepatic sinusoids while the accompanied VEGF release implying a therapeutic anti-aging target. The lobation of the goat liver formed from four lobes, left undivided large ventral located, undivided right, quadrate and caudate lobe. The hepatic artery branched into right, left and middle branches which ramified to each lobes of the liver.