Abstract: Quality of nursing care of hemodialysis patient should be conforming to standards of care, which are considered as a starting point for better and excellent practice. Aim of this research was to evaluate the efficacy of education and training interventions on nurse’s compliance to standard of nursing care for hemodialsis patient. Design: Quasi-experimental design was used. Setting: this study was conducted in hemodialysis unit at El-Menia University Hospital, Egypt. Sample: Convenience samples of 41 nurses were female, experienced in hemodialysis care of patients Dec 2016 - Nov 2017. Tools: A questionnaire examining knowledge and an observational checklist for the performance were used for data collection. Results: Reveal that (68.3%) of nurses weren't aware of hemodialysis nursing care standards. More than half of nurses (61.0% - 56.1%) hadn't attended conference during the past 5 years and attended hadn't educational lectures respectively .There were increasing percent in nurses achieved very good and excellent overall total knowledge and performance in the post-test and the follow-up compared with the pre -test periods, increase in total mean scores for the observations related to overall performance of infection control. there was a strong positive relationship between nurses knowledge and their performance were dedicated in the post tests at (P< 0.001**). Conclusion: Based on the results of this study, education and training interventions were effective ways in achieved progressive improvement of the nurses' knowledge and skills, toward adopted standard of nursing care for hemodialsis patient.